Planning a trip to Florence and want to see the best art in the city? Here’s my guide to 30 must see famous art works and masterpieces in Florence. Florence is home to scores of museums, palaces, churches, and cloisters that contain incredible masterpieces. The art in Florence is dominated by the Italian Renaissance. Within Florence’s medieval walls, lived the greatest painters of the time — Leonardo da Vinci, Michelangelo, Giotto, Masaccio, Botticelli, Fra Angelico, and Giorgio Vasari.