I'll always be a fan of Dramione. Seriously, the whole "inter-house unity" bit throughout the books and umm. you don't get a major character pairing between Slytherin and Gryffindor? I do love Ron and Hermione though.
I love this post because of Hedwig, but honestly, we got Longbottomed by the whole damn cast! Puberty hit these guys with the sexy stick about a thousand times! Tell me there wasn't magic involved here!