Scientists turn food poisoning microbe into powerful cancer fighter
Structural basis of RNA polymerase III transcription initiation | Nature, 2018
Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade | Science Translational Medicine, 2018
Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors | Science, 2018
A new way of shutting down the the multidrug resistance pumps in cancer cells is found. Silica-carbon nanoparticles coated with pyrivate are targeted to the mitochondria of malignant cells and activated with near infrared light where they cause oxidation of NADH and stall ATP production. Without ATP MDRPs cannot function which creates a 5days window of opportunity to apply chemotherapy. [Nature Communications, 2018]
Injecting DNA (CpG) together with OX-40 antibody into tumor activates a potent immune response leading to tumor shrinkage in mice. (CpG stimulates dendritic cells and OX-40 - T cells) [Science Trans Med, 2018]
We are more than the sum of our genes. Epigenetic mechanisms modulated by environmental cues such as diet, disease or lifestyle take a major role in regulating the DNA by switching genes on and off. It has been long debated .
Cell cannibalism in tumour samples has been observed for over a century, yet this unusual behaviour is not well studied. New research led by scientists at the Babraham Institute, Cambridge reveals a new mechanism driving .
Grid tilt is successfully applied in single particle cryoEM [Nature Methods,