Danyil
Další nápady od uživatele Danyil
Gene Therapy Advanced by Structural Study of Potential Viral Vectors | GEN Genetic Engineering & Biotechnology News - Biotech from Bench to Business | GEN

Gene Therapy Advanced by Structural Study of Potential Viral Vectors | GEN Genetic Engineering & Biotechnology News - Biotech from Bench to Business | GEN

Pieced-together viral genomes contradict view that giant viruses represent a distinct branch of life

Pieced-together viral genomes contradict view that giant viruses represent a distinct branch of life

Cellular levels of NAD+ are sensed by DBC1 by direct binding. As NAD levels decrease with aging DBC1 responds by binding to numerous partner proteins. One of them is  DNA repair enzyme PARP1 on which DBC1 exerts inhibitory action. This molecular mechanism largely explains the increased amount of DNA damage in aging tissues. NAD precursor NMN can reverse this effect and can also reduce radiation DNA damage [Science, 2017]

Cellular levels of NAD+ are sensed by DBC1 by direct binding. As NAD levels decrease with aging DBC1 responds by binding to numerous partner proteins. One of them is DNA repair enzyme PARP1 on which DBC1 exerts inhibitory action. This molecular mechanism largely explains the increased amount of DNA damage in aging tissues. NAD precursor NMN can reverse this effect and can also reduce radiation DNA damage [Science, 2017]

Again about cancer-causing mutations and their apparent randomness. In nature too http://www.nature.com/news/dna-typos-to-blame-for-most-cancer-mutations-1.21696?WT.mc_id=FBK_NatureNews#/b3 + check the references!

Again about cancer-causing mutations and their apparent randomness. In nature too http://www.nature.com/news/dna-typos-to-blame-for-most-cancer-mutations-1.21696?WT.mc_id=FBK_NatureNews#/b3 + check the references!

The concept of selfish immune system that employs adenosine signaling to secure enough nutrients to fight the pathogen. Parallels with how cancer-promoted cahexia. Study of T Doležal showing the central role of adenosine for major metabolic switches http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002135

The concept of selfish immune system that employs adenosine signaling to secure enough nutrients to fight the pathogen. Parallels with how cancer-promoted cahexia. Study of T Doležal showing the central role of adenosine for major metabolic switches http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002135

Researchers at UC San Diego School of Medicine and Jacobs School of Engineering developed a new method to search for synthetic-lethal gene combinations. Method is based on the dual guide RNA CRISPR/Cas9. They tested all possible pairs of 73 genes on three different cancer cell lines. More than a hundred new drugable interactions found an of them ~75 %  were confirmed by combinatorial application of corresponding small molecule inhibitors in vitro [Nature, 2017]

Researchers at UC San Diego School of Medicine and Jacobs School of Engineering developed a new method to search for synthetic-lethal gene combinations. Method is based on the dual guide RNA CRISPR/Cas9. They tested all possible pairs of 73 genes on three different cancer cell lines. More than a hundred new drugable interactions found an of them ~75 % were confirmed by combinatorial application of corresponding small molecule inhibitors in vitro [Nature, 2017]

Phosphatidylinositol 3-kinase delta target inhibitors cause the genome instability by indirectly promoting Activation-induced cytidine deaminase (AID) in healthy and cancerous B cells [Nature, 2017]

Phosphatidylinositol 3-kinase delta target inhibitors cause the genome instability by indirectly promoting Activation-induced cytidine deaminase (AID) in healthy and cancerous B cells [Nature, 2017]

New method of genetic engineering indispensable tool in biotechnological applications // Custom restriction enzyme based on Pyrococcus furiosum Argonaut protein cut the target denatured DNA @ 75 oC. The specificity is achieved by Watson-Crick base pairing much like in Cas9. Enzyme leaves long overhangs suitable for high precision cloning.

New method of genetic engineering indispensable tool in biotechnological applications // Custom restriction enzyme based on Pyrococcus furiosum Argonaut protein cut the target denatured DNA @ 75 oC. The specificity is achieved by Watson-Crick base pairing much like in Cas9. Enzyme leaves long overhangs suitable for high precision cloning.

Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer points to new potential targets [Nature 2017]

Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer points to new potential targets [Nature 2017]

Twelve percent of all unknown protein family structures revealed by into coevolving pairs of amino acid residues involved in maintaining secondary structure of proteins

Twelve percent of all unknown protein family structures revealed by into coevolving pairs of amino acid residues involved in maintaining secondary structure of proteins