Danyil
Další nápady od uživatele Danyil
Scientists are providing the clearest view yet of an intact bacterial microcompartment, revealing at atomic-level resolution the structure and assembly of the organelle's protein shell. This work could benefit research in bioenergy and pathogenesis, and it could lead to new methods of bioengineering bacteria for beneficial purposes [Science, 2017]

Scientists are providing the clearest view yet of an intact bacterial microcompartment, revealing at atomic-level resolution the structure and assembly of the organelle's protein shell. This work could benefit research in bioenergy and pathogenesis, and it could lead to new methods of bioengineering bacteria for beneficial purposes [Science, 2017]

The novel PTEN-dependent tumor suppression pathway is discovered. It is based on the ability of PTEN to induce Ca-dependent apoptosis. The drug, geranylgeranyltransferase inhibitor GGTI-2418 is restoring the normal phenotype in defective PTEN cancer cell making them sensitive to photodynamic therapy. [Nature, 2017]

The novel PTEN-dependent tumor suppression pathway is discovered. It is based on the ability of PTEN to induce Ca-dependent apoptosis. The drug, geranylgeranyltransferase inhibitor GGTI-2418 is restoring the normal phenotype in defective PTEN cancer cell making them sensitive to photodynamic therapy. [Nature, 2017]

PD-L2 Helps Predict Immunotherapy Responsiveness for Head and Neck Cancer [Clinical Cancer Research, 2017]

PD-L2 Helps Predict Immunotherapy Responsiveness for Head and Neck Cancer [Clinical Cancer Research, 2017]

Cancers deficient in mismatch repair pathways are more susceptible to immune checkpoint blockade therapy with PD-1 inhibitor possibly because of greater numbers of tumor neoantigenes [Science, 2017]

Cancers deficient in mismatch repair pathways are more susceptible to immune checkpoint blockade therapy with PD-1 inhibitor possibly because of greater numbers of tumor neoantigenes [Science, 2017]

A computer-designed protein blocks hemagglomeratinin of influenza virus preventing it from entering cells in the lab in vitro and mouse model [Nature Biotechnology, 2017]

A computer-designed protein blocks hemagglomeratinin of influenza virus preventing it from entering cells in the lab in vitro and mouse model [Nature Biotechnology, 2017]

Researchers have discovered how the Rad52 protein is a crucial player in RNA-dependent DNA double-strand break repair. The essentiality of this protein in BRCA-deficient cancer cells points to a new therapeutic target for cancer [Molecular Cell, 2017].

Researchers have discovered how the Rad52 protein is a crucial player in RNA-dependent DNA double-strand break repair. The essentiality of this protein in BRCA-deficient cancer cells points to a new therapeutic target for cancer [Molecular Cell, 2017].

New approach in T-cell therapy to treat cancer [Cancer Research 2018]. It consists in fusing together the inhibitory surface receptor PD-1 with activating cytoplasmic domain of CD28 (PD-1:28). This results in much higher proliferation and cytotoxic activity of T cells in tumor mileu. This treatment affects only avidity but not affinity of T cells, thus, making them less likely to cause autoimmunity and toxicity. This modification is compatible with adoptive T cell transfer.

New approach in T-cell therapy to treat cancer [Cancer Research 2018]. It consists in fusing together the inhibitory surface receptor PD-1 with activating cytoplasmic domain of CD28 (PD-1:28). This results in much higher proliferation and cytotoxic activity of T cells in tumor mileu. This treatment affects only avidity but not affinity of T cells, thus, making them less likely to cause autoimmunity and toxicity. This modification is compatible with adoptive T cell transfer.

Unfolded Protein Response not only affects healthy cells in tumor microenvironment but also propagates through the tumor influencing intracellular signaling landscape and contributing to the survival of malignant cells and drug resistance. [Science Signaling, 2017]

Unfolded Protein Response not only affects healthy cells in tumor microenvironment but also propagates through the tumor influencing intracellular signaling landscape and contributing to the survival of malignant cells and drug resistance. [Science Signaling, 2017]

Engineered exosomes with CD47 on the surface effectively deliver small interfering RNAs agains mutated version of KRAS (G12D) into pancreatic ductal adenocarcinoma cells. [Nature, 2017]

Engineered exosomes with CD47 on the surface effectively deliver small interfering RNAs agains mutated version of KRAS (G12D) into pancreatic ductal adenocarcinoma cells. [Nature, 2017]

Старение и рак – наследие колониальных предков. Любопытная взгляд на канцерогенез, но не более.

Старение и рак – наследие колониальных предков. Любопытная взгляд на канцерогенез, но не более.