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LTBP3 (part of transforming growth factor beta signaling) promotes early metastatic events during cancer cell dissemination (neovascularization/intravasation) | Oncogene, 2017

LTBP3 (part of transforming growth factor beta signaling) promotes early metastatic events during cancer cell dissemination (neovascularization/intravasation) | Oncogene, 2017

Structural basis of RNA polymerase III transcription initiation | Nature, 2018

Structural basis of RNA polymerase III transcription initiation | Nature, 2018

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade | Science Translational Medicine, 2018

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade | Science Translational Medicine, 2018

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors | Science, 2018

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors | Science, 2018

A new way of shutting down the the multidrug resistance pumps in cancer cells is found. Silica-carbon nanoparticles coated with pyrivate are targeted to the mitochondria of malignant cells and activated with near infrared light where they cause oxidation of NADH and stall ATP production. Without ATP MDRPs cannot function which creates a 5days window of opportunity to apply chemotherapy. [Nature Communications, 2018]

A new way of shutting down the the multidrug resistance pumps in cancer cells is found. Silica-carbon nanoparticles coated with pyrivate are targeted to the mitochondria of malignant cells and activated with near infrared light where they cause oxidation of NADH and stall ATP production. Without ATP MDRPs cannot function which creates a 5days window of opportunity to apply chemotherapy. [Nature Communications, 2018]

Injecting DNA (CpG) together with OX-40 antibody into tumor activates a potent immune response leading to tumor shrinkage in mice. (CpG stimulates dendritic cells and OX-40 - T cells) [Science Trans Med, 2018]

Injecting DNA (CpG) together with OX-40 antibody into tumor activates a potent immune response leading to tumor shrinkage in mice. (CpG stimulates dendritic cells and OX-40 - T cells) [Science Trans Med, 2018]

The revolutionary embryo gene editing technique recent published in Nature might not worked at all

Doubts raised about CRISPR gene-editing study in human embryos

FDA approves genetically engineered T cells for the treatment of acute lymphoblastic leukemia. T cells are devised to carry the chimeric antigen receptor (CAR) that recognizes tumor antigens which are specific for each patient (Sciencemag, 2017)

cost of cancer: new drugs show success at a steep price - Reuters: Reuters The cost of cancer: new drugs show success at a steep price…

For the first time epigenetic inheritance is observed at the molecular level in Drosophila: zygote needs mother's histone methyltransferase to properly regulate the expression of developmental genes. [Science, 2017]

We are more than the sum of our genes. Epigenetic mechanisms modulated by environmental cues such as diet, disease or lifestyle take a major role in regulating the DNA by switching genes on and off. It has been long debated .

Two groups of scientists successfully applied a personalized immunotherapy approach against melanoma. By sequencing tumor exomes they first identified the repertoire of neoantigenes specific to each patient. Then, they devised RNA- or peptide-based vaccines to target 10 to 20 neoantigenes at a time either with or without PD-1 inhibitor. Results look very promising [both papers were published in Nature, 2017]

Personalized cancer vaccines show glimmers of success Treatments tailored to a persons individual cancer mutations train immune system to attack tumours.

Entosis - a type of cellular cannibalism - is widespread in tumors. It usually depends on detachment from extracellular matrix. Here researchers report a new mechanism of entosis which is triggered by a faulty cell division [eLife, 2017]

Cell cannibalism in tumour samples has been observed for over a century, yet this unusual behaviour is not well studied. New research led by scientists at the Babraham Institute, Cambridge reveals a new mechanism driving .

Grid tilt is successfully applied in single particle cryoEM [Nature Methods, 2017]

Grid tilt is successfully applied in single particle cryoEM [Nature Methods,

RNase III called Drosha, which is involved in miRNA processing in the eukaryotic nucleus, first evolved as antiviral protein targeting RNA dependent RNA polymerase and viral replication intermediates. [Nature, 2017]

RNase III called Drosha, which is involved in miRNA processing in the eukaryotic nucleus, first evolved as antiviral protein targeting RNA dependent RNA polymerase and viral replication intermediates.

Researchers identify one of the cases of immune checkpoint blockade failure: the cytotoxic T cell exhaustion. By blocking de novo DNA methylation in activated CD8 T cells they were able to restore their effector functions despite chronic stimulation during a persistent viral infection. Similar approach worked in cancer (both experiments were done on mouse models) [Cell, 2017]

Altering DNA methylation may reverse T-cell exhaustion, improve checkpoint blockade

Scientists are providing the clearest view yet of an intact bacterial microcompartment, revealing at atomic-level resolution the structure and assembly of the organelle's protein shell. This work could benefit research in bioenergy and pathogenesis, and it could lead to new methods of bioengineering bacteria for beneficial purposes [Science, 2017]

Scientists are providing the clearest view yet of an intact bacterial microcompartment, revealing at atomic-level resolution the structure and assembly of the organelle’s protein shell.